Serotype-independent protective activity of recombinant pneumolysin in a model of systemic infection caused by <i>Streptococcus pneumoniae</i> serotypes 4 and 6B

Background. The development of a pneumococcal vaccine with serotype-independent activity is relevant for the whole world, as this due to high prevalence Streptococcus pneumoniae ( S. ), constant change pathogen serotypes and growth antibiotic-resistant strains. In previous experiments, we revealed protective effect immunization recombinant pneumolysin (rPly) in model systemic infection caused by serotype 3. Aim. Study rPly. Materials methods. Strains 4 6B were used. Mice immunized intraperi-toneally two or three times an interval 14 days To assess rPly, animals after double triple infected intraperitoneally . Results. rPly at dose 25 μg protected mice from intraperitoneal pneu- moniae 4, efficiency index increased 2 compared control. immunization, 6B, 6.61 Conclusion. protects different , which allows us consider it promising drug vaccines activity.